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               Shaobin Zhu

                CEO
&CTO

   



   
        厦门大学化学系 学士 (2002-2006)

 
        厦门大学分析化学专业 博士 (2006-2012)
 
        美国爱荷华州立大学化学系和美国能源部艾姆斯国家实验室 博士后 (2013-2014)
 
        厦门福流生物科技有限公司 总经理 (2014-)
 
     主要从事生化分析与生物传感研究,致力于发展先进的纳米颗粒表征技术以解决制约纳米生物、纳米医药发展的突出难题,拥有仪器、化学、生物等多学科交叉的学术背景;攻读博士期间师从厦门大学颜晓梅教授,针对纳米生物前沿基础研究迫切需要表征技术的科学问题,以原理和技术创新为核心,通过科研装置的自主研制,发展了多种灵敏、快速、特异、准确的生化分析新方法;在美国爱荷华州立大学和美国能源部艾姆斯国家实验室(Iowa State University & Ames Laboratory, U.S. Department of Energy)有两年的博士后经历,从事高分辨成像技术研究;在J. Am. Chem. Soc., ACS nano, Anal. Chem.等国际化学主流期刊发表SCI论文21篇;2015年获得厦门市高层次留学人员身份认定,2017年厦门市A类青年创新人才计划

Experience

CEO&CTO,  NanoFCM INC. 
2014 – Present  Xiamen, Fujian
NanoFCM provides a versatile and powerful platform-HSFCM for the multiparameter characterization of multifunctional NPs and viruses at the single-particle level. Light scattering is used for the measurement of nanoparticle size and size distributions. Fluorescence detection is used to analyze the chemical properties of nanoparticles. Thus, size, concentration, chemical attributes, and biological features of biomolecules conjugated on the nanoparticle surface can be characterized, and correlated analysis of these attributes can be facilitated at the single-nanoparticle level.
 
Postdoctoral Associate research mainly focuses on single particle tracking and super-resolution imaging in chemical and biological systems
 
PhD reserach focuses on the development of high sensitivity flow cytometry (HSFCM) and its applications in quantitative characterization of individual nanoparticles and viruses. Light scattering is used to measure nanoparticle size and size distributions, and fluorescence detection is used to analyze the chemical properties of nanoparticles. At present, HSFCM allows the individual detection of 6.7 nm gold nanoparticles and 24 nm low refractive index nanoparticles or viruses in suspension by intensity-based real-time light-scattering detection below the Level of Single Fluorescent Molecules.

 

Skills and Techniques

·   Instrument development, including 3D modeling, design and process of parts, and data acquisition and processing software development using LabVIEW.
·   Optical detection and superresolution imaging of single nanoparticles and molecules in chemical and biological systems.
·   Flow cytometry techniques
·   Proficient with professional drawing software: Photoshop, AutoCAD, SolidWorks, 3ds Max.
·   Interdisciplinary background in chemistry, nanoscience, physics, and biology.



Publications

1.         Zhu S, Ma L, Wang S, Chen C, Zhang W, Yang L, Hang W, Nolan JP, Wu L, Yan X. Light-Scattering Detection below the Level of Single Fluorescent Molecules for High-Resolution Characterization of Functional Nanoparticles. ACS Nano. 2014;8(10):10998-1006.
2.         Ma L§, Zhu S§, Tian Y, Zhang W, Wang S, Chen C, Wu L, Yan X*. Label-Free Analysis of Single Viruses with a Resolution Comparable to That of Electron Microscopy and the Throughput of Flow Cytometry. Angew. Chem. Int. Ed. 2016, 55, 10239-10243. (§, first coauthor)
3.         Zhang S§, Zhu S§, Yang L, Zheng Y, Gao M, Wang S, Zeng J-z, Yan X. High-Throughput Multiparameter Analysis of Individual Mitochondria. Analytical Chemistry. 2012;84(15):6421-8. (§, first coauthor)
4.         Zhu S, Wang S, Yang L, Huang T, Yan X. Progress in the development of techniques based on light scattering for single nanoparticle detection. Science China-Chemistry. 2011;54(8):1244-53.
5.         Zhu S, Yang L, Long Y, Gao M, Huang T, Hang W, Yan X. Size Differentiation and Absolute Quantification of Gold Nanoparticles via Single Particle Detection with a Laboratory-Built High-Sensitivity Flow Cytometer. Journal of the American Chemical Society. 2010;132(35):12176-8.
6.         Dong B, Yang X, Zhu S, BasshamD, Fang N. Stochastic Optical Reconstruction Microscopy Imaging of Microtubule Arrays in IntactArabidopsis thaliana Seedling Roots. Scientific Reports. 2015, 5, 15694
7.         Chen C; Zhang X; Zhang S; Zhu S; Xu J; Zheng Y;,Han J; Zeng J; Yan X*.Quantification of protein copy number in single mitochondria: The Bcl-2 family proteins. Biosensors and Bioelectronics, 2015, 74, 476-482.
8.         Zhang X, Zhang S, Zhu S, Chen S, Han J, Gao K, Zeng J-z, Yan X. Identification of Mitochondria-Targeting Anticancer Compounds by an in Vitro Strategy. Analytical Chemistry. 2014;86(11):5232-7.
9.         Xu F, Zhu L, Zhu S, Yan X, Xu H-C. Electrochemical intramolecular aminooxygenation of unactivated alkenes. Chemistry (Weinheim an der Bergstrasse, Germany). 2014;20(40):12740-4.
10.     Wu L, Luan T, Yang X, Wang S, Zheng Y, Huang T, Zhu S, Yan X. Trace Detection of Specific Viable Bacteria Using Tetracysteine-Tagged Bacteriophages. Analytical Chemistry. 2014;86(1):907-12.
11.     Lesoine MD, Bobbitt JM, Zhu S, Fang N, Smith EA. High angular-resolution automated visible-wavelength scanning angle Raman microscopy. Analytica Chimica Acta. 2014;848:61-6.
12.     Yang L, Huang T, Zhu S, Zhou Y, Jiang Y, Wang S, Chen Y, Wu L, Yan X. High-throughput single-cell analysis of low copy number beta-galactosidase by a laboratory-built high-sensitivity flow cytometer. Biosensors & Bioelectronics. 2013;48:49-55.
13.     Gu Y, Ha JW, Augspurger AE, Chen K, Zhu S, Fang N. Single Particle Orientation and Rotational Tracking (SPORT) in biophysical studies. Nanoscale. 2013;5(22):10753-64.
14.     Chen C, Zhu S, Huang T, Wang S, Yan X. Analytical techniques for single-liposome characterization. Analytical Methods. 2013;5(9):2150-7.
15.     Yang L, Zhou Y, Zhu S, Huang T, Wu L, Yan X. Detection and Quantification of Bacterial Autofluorescence at the Single-Cell Level by a Laboratory-Built High-Sensitivity Flow Cytometer. Analytical Chemistry. 2012;84(3):1526-32.
16.     Wu L, Huang T, Yang L, Pan J, Zhu S, Yan X. Sensitive and Selective Bacterial Detection Using Tetracysteine-Tagged Phages in Conjunction with Biarsenical Dye. Angewandte Chemie-International Edition. 2011;50(26):5873-7.
17.     Yang L, Wu L, Zhu S, Long Y, Hang W, Yan X. Rapid, Absolute, and Simultaneous Quantification of Specific Pathogenic Strain and Total Bacterial Cells Using an Ultrasensitive Dual-Color Flow Cytometer. Analytical Chemistry. 2010;82(3):1109-16.
18.     Yang L, Zhu S, Hang W, Wu L, Yan X. Development of an Ultrasensitive Dual-Channel Flow Cytometer for the Individual Analysis of Nanosized Particles and Biomolecules. Analytical Chemistry. 2009;81(7):2555-63.
19.     Yang L, Zhu S, Hang W, Yan X. Development of a single-molecule flow analyzer. Chemical Journal of Chinese Universities. 2008, 29 (8), 1549-51.